They had mild Covid. Then their serious symptoms kicked in.


Written by Pam Belluck

In the autumn, after Samar Khan got here down with a mild case of COVID-19, she anticipated to get well and return to her earlier energetic life in Chicago. After all, she was simply 25, and wholesome.

But weeks later, she mentioned, “this weird constellation of symptoms began to set in.”

She had blurred imaginative and prescient encircled with unusual halos. She had ringing in her ears, and all the things started to odor like cigarettes or Lysol. One leg began to tingle, and her arms would tremble whereas placing on eyeliner.

She additionally developed “really intense brain fog,” she mentioned. Trying to focus on a name for her job in monetary providers, she felt as if she had simply come out of anesthesia. And throughout a debate about politics along with her husband, Zayd Hayani, “I didn’t remember what I was trying to say or what my stance was,” she mentioned.

By the tip of the yr, Khan was referred to a particular clinic for COVID-related neurological symptoms at Northwestern Memorial Hospital in Chicago, which has been evaluating and counseling lots of of individuals from throughout the nation who’re experiencing related issues.

Now, the clinic, which sees about 60 new sufferers a month, in-person and through telemedicine, has revealed the primary examine centered on long-term neurological symptoms in individuals who have been by no means bodily sick sufficient from COVID-19 to want hospitalization, together with Khan.

The examine of 100 sufferers from 21 states, revealed Tuesday in The Annals of Clinical and Translational Neurology, discovered that 85% of them skilled 4 or extra neurological points like mind fog, complications, tingling, muscle ache and dizziness.

“We are seeing people who are really highly, highly functional individuals, used to multitasking all the time and being on top of their game, but, all of a sudden, it’s really a struggle for them,” mentioned Dr. Igor J. Koralnik, the chief of neuro-infectious illnesses and world neurology at Northwestern Medicine, who oversees the clinic and is the senior writer of the examine.

The report, during which the common affected person age was 43, underscores the rising understanding that for many individuals, lengthy COVID may be worse than their preliminary bouts with the an infection, with a cussed and sophisticated array of symptoms.

This month, a examine that analyzed digital medical data in California discovered that almost a 3rd of the individuals fighting lengthy COVID symptoms — like shortness of breath, cough and belly ache — didn’t have any indicators of sickness within the first 10 days after they examined optimistic for the coronavirus. Surveys by patient-led teams have additionally discovered that many COVID survivors with long-term symptoms have been by no means hospitalized for the illness.

In the Northwestern examine, many skilled symptoms that fluctuated or endured for months. Most improved over time, however there was extensive variation.

“Some people after two months are 95% recovered, while some people after nine months are only 10% recovered,” Koralnik mentioned. Five months after contracting the virus, sufferers estimated, they felt on common solely 64% recovered.

Across the nation, docs who’re treating individuals with post-COVID neurological symptoms say the examine’s findings echo what they’ve been seeing.

“We need to take this seriously,” mentioned Dr. Kathleen Bell, chairwoman of the bodily drugs and rehabilitation division on the University Texas Southwestern Medical Center, who was not concerned within the new examine. “We can either let people get worse and the situation gets more complicated, or we can really realize that we have a crisis.”

Bell and Koralnik mentioned most of the symptoms resembled these of people that had concussions or traumatic mind accidents or who had psychological fogginess after chemotherapy.

In the case of COVID, Bell mentioned, consultants consider that the symptoms are attributable to “an inflammatory reaction to the virus” that may have an effect on the mind in addition to the remainder of the physique. And it is smart that some individuals expertise a number of neurological symptoms concurrently or in clusters, Bell mentioned, as a result of “there’s only so much real estate in the brain, and there’s a lot of overlap” in areas answerable for completely different mind features.

“If you have inflammation disturbances,” she mentioned, “you can very well have cognitive effects and things like emotional effects. It’s really hard to have one neurological problem without having multiple.”

In the Northwestern examine, Koralnik mentioned that as a result of coronavirus testing was troublesome to acquire early within the pandemic, solely half of the members had examined optimistic for the coronavirus, however all had the preliminary bodily symptoms of COVID-19. The examine discovered little or no distinction between those that had examined optimistic and those that had not. Koralnik mentioned that those that examined detrimental tended to contact the clinic a few month later in the middle of the illness than those that examined optimistic, probably as a result of some had spent weeks being evaluated or attempting to have their issues addressed by different docs.

Khan was among the many members who had a detrimental check for the virus, however she mentioned she later examined optimistic for coronavirus antibodies, proof that she had been contaminated.

In the Northwestern examine, 43% of the sufferers had melancholy earlier than having COVID-19; 16% had earlier autoimmune illnesses, the identical share of sufferers who had earlier lung illness or had struggled with insomnia.

Experts cautioned that as a result of the examine was comparatively small, these preexisting circumstances would possibly or won’t be consultant of all long-term sufferers.


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