Researchers test new combination therapy for head and neck cancer

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Washington: Researchers on the University of Cincinnati have examined a new combination therapy in animal fashions to see if they may discover a method to make an already efficient therapy even higher. Since they`re utilizing a Food and Drug Administration-approved drug to do it, this might assist people before later.

These findings are printed within the journal Cancer Letters. Christina Wicker, PhD, a postdoctoral fellow within the lab of Vinita Takiar, MD, PhD, led this analysis which she says will hopefully prolong the lives of sufferers at some point.”Head and neck cancer, like any cancer, is truly life-altering,” she says.

“Head and neck cancer could impact your throat, tongue or nose, and patients often can`t swallow, talk or eat; it truly takes away some of the most social, enjoyable parts of life.”

Researchers on this examine mixed radiation therapy with a drug (telaglenastat) that stops a key enzyme in a cell pathway that turns into altered in cancer cells, inflicting these cells to develop quickly and resist therapy. Wicker says this drug has already been studied in a number of medical trials to see if it might enhance therapy of varied cancers.

“Until now, no one has examined if this drug has the potential to improve radiation treatment in head and neck cancer. Most importantly, this drug compound has been well tolerated by patients and causes minimal side effects,” she says.

Using animal fashions, researchers discovered that the drug alone decreased the expansion of head and neck cancer cells as much as 90 per cent, and it additionally elevated the efficacy of radiation in animals with head and neck tumours by 40 per cent. “With these results, and especially with previous clinical trials showing that the drug is well tolerated by patients, there is the potential to move more rapidly into head and neck cancer clinical trials,” Wicker says.

“In the future, we hope this drug will be used to make radiation treatments for head and neck cancer even more effective.” Currently, the most typical therapy for that cancer is radiation therapy, however cancer finally returns in as much as half of the sufferers, Wicker says, and usually it doesn`t reply as positively to therapy the second time round.”When [traditional] drugs are less effective, cancer growth becomes difficult to control, which can lead to the cancer quickly spreading to other organs,” she says.”It is very important that scientists and clinicians develop new cancer treatments to improve treatment of this type of cancer, and hopefully our findings will provide one more option to help patients.”

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